Socioeconomic status and cell aging in children

被引：87

作者：

Needham, Belinda L. ^{[1
]}

Fernandez, Jose R. ^{[2
]}

Lin, Jue ^{[3
]}

Epel, Elissa S. ^{[4
]}

Blackburn, Elizabeth H. ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Dept Sociol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

来源：

SOCIAL SCIENCE & MEDICINE | 2012年 / 74卷 / 12期

关键词：

Telomere length; Socioeconomic status; Children; USA; PHYSICAL-ACTIVITY QUESTIONNAIRE; TELOMERE LENGTH; HEALTH; BLOOD; STRESS; AGE; ASSOCIATION; DISPARITIES; LEUKOCYTES; MORTALITY;

D O I：

10.1016/j.socscimed.2012.02.019

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Theory suggests that chronic stress associated with disadvantaged social status may lead to acceleration in the rate of decline in physiological functioning. The purpose of this study is to examine the association between parental socioeconomic status (SES) and leukocyte telomere length (LTL), a marker of cell aging, in children. We examined SES and LTL in 70 white and black US children aged 7-13 who participated in the community-based AMERICO (Admixture Mapping for Ethnic and Racial Insulin Complex Outcomes) study. LTL was assessed using the polymerase chain reaction (PCR) method. Parental education was positively associated with child LTL, net of controls for sex, age, race/ethnicity, and family income. Compared to children with at least one college-educated parent, children whose parents never attended college had telomeres shorter by 1,178 base pairs, which is roughly equivalent to 6 years of additional aging. Socioeconomic disparities in cell aging are evident in early life, long before the onset of age-related diseases. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1948 / 1951

页数：4

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