Application of accelerator mass spectrometry (AMS) in early drug development. Part 2. Synthesis and certification of 14C-labelled compounds

被引:0
作者
Lipner, Grzegorz [1 ]
Luniewski, Wojciech [1 ]
Maruszak, Wioletta [2 ]
Grynkiewicz, Grzegorz
机构
[1] Inst Farmaceuty, Zakladzie Chem, PL-01793 Warsaw, Poland
[2] Inst Farmaceuty, Zakladzie Analityki Badawczej, PL-01793 Warsaw, Poland
来源
PRZEMYSL CHEMICZNY | 2012年 / 91卷 / 03期
关键词
SUMATRIPTAN; PHARMACOKINETICS; PARACETAMOL; METABOLISM; ACETAMINOPHEN; MICRODOSE;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A review, with 30 refs., of methods for synthesis and testing of C-14-labelled p-HOC6H4NHCOMe and 1-[3-(2-aminoethyl)-1H-indol-5-yl]-N-methylmethansulfonamide.
引用
收藏
页码:320 / 325
页数:6
相关论文
共 32 条
  • [1] [Anonymous], 1997, Pat. wegierski, Patent No. 76139
  • [2] [Anonymous], IMP NEW DRUG SUBST
  • [3] [Anonymous], EMEACHMPQWP306970200
  • [4] Barrow A, 1997, BIOPHARM DRUG DISPOS, V18, P443
  • [5] Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
    Bessems, JGM
    Vermeulen, NPE
    [J]. CRITICAL REVIEWS IN TOXICOLOGY, 2001, 31 (01) : 55 - 138
  • [6] A comparison of the effects of intravenous tramadol, codeine, and morphine on gastric emptying in human volunteers
    Crighton, IM
    Martin, PH
    Hobbs, GJ
    Cobby, TF
    Fletcher, AJP
    Stewart, PD
    [J]. ANESTHESIA AND ANALGESIA, 1998, 87 (02) : 445 - 449
  • [7] DAVENPORT KG, 1988, Patent No. 251552
  • [8] CHARACTERIZATION OF THE ENZYME RESPONSIBLE FOR THE METABOLISM OF SUMATRIPTAN IN HUMAN LIVER
    DIXON, CM
    PARK, GR
    TARBIT, MH
    [J]. BIOCHEMICAL PHARMACOLOGY, 1994, 47 (07) : 1253 - 1257
  • [9] DIXON CM, 1993, DRUG METAB DISPOS, V21, P761
  • [10] Dowle M.D., 1985, Pat. USA, Patent No. 4816470