Stimulatory effects of laser wavelengths on proliferation and angiogenesis of colon cancer: in vitro and in vivo evaluations

被引：0

作者：

Kim, Hyejin ^{[1
,2
]}

Kim, Yeongeun ^{[2
,3
]}

Kang, Hyun Wook ^{[1
,2
,3
]}

机构：

[1] Pukyong Natl Univ, Ind Convergence Bion Engn 4 0, Busan, South Korea

[2] Pukyong Natl Univ, Marine Integrated Biomed Technol Ctr, Busan, South Korea

[3] Pukyong Natl Univ, Dept Biomed Engn, Busan, South Korea

来源：

SPIE ADVANCED BIOPHOTONICS CONFERENCE (SPIE ABC 2021) | 2021年 / 12159卷

关键词：

Low-level laser therapy; photobiomodulation; colon cancer; proliferation; angiogenesis;

D O I：

10.1117/12.2626057

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Photobiomodulation (PBM) has been investigated for stimulation biological processes including wound healing and pain recovery. Therefore, in this study, the effects of PBM under Blue light (BL), Visible (VIS), and NIR laser irradiations on prostate cancer cells were evaluated to establish safety margins. In in vitro and in vivo studies, BL showed upregulated expression of VEGF, HIF-1 alpha, EGFR, and MMP-9. These results suggested that BL can stimulate cancer cell proliferation, angiogenesis, and hypoxia, leading to aggressive tumor growth. These outcomes can provide a safety margin for the response of PBM-related stimulation after laser treatment.

引用

页数：4

共 5 条

[1] Low-Level Laser Therapy Stimulates Proliferation in Head and Neck Squamous Cell Carcinoma Cells [J].