Haematological cancers in pregnancy

被引:135
作者
Brenner, Benjamin [1 ,2 ]
Avivi, Irit [1 ,2 ]
Lishner, Michael [3 ,4 ]
机构
[1] Technion Israel Inst Technol, Dept Hematol & Bone Marrow Transplantat, IL-31096 Haifa, Israel
[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
[3] Meir Med Ctr, Dept Med, Kefar Sava, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; NON-HODGKINS-LYMPHOMA; ACUTE PROMYELOCYTIC LEUKEMIA; PRIMARY BREAST LYMPHOMA; ESSENTIAL THROMBOCYTHEMIA; INTERFERON-ALPHA; CHEMOTHERAPEUTIC-AGENTS; MULTIPLE-MYELOMA; IMATINIB THERAPY;
D O I
10.1016/S0140-6736(11)61348-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Haematological cancer in pregnancy, although rare, poses a substantial risk to both mother and fetus. Hodgkin's lymphoma is the most common, followed by non-Hodgkin lymphoma and acute leukaemia. Diagnosis of haematological cancers is challenged by an overlap of the disease and gestation-related symptoms and limitations of imaging studies in pregnancy. Data for safety and effectiveness of therapy are scarce and mostly retrospective. This report provides updated guidance for management, focusing on chemotherapy and biological agents. The primary goal of treatment is to preserve the mother's health; hence, pregnancy termination is often advisable at early stages, allowing delivery of adequate therapy. However, at later gestational stages treatment is often feasible. Pregnancy-related hypercoagulability, augmented by cancer, often necessitates thromboprophylaxis. The consequences and complex management of haematological cancer during pregnancy emphasise the need for collaborative research, focusing on basic mechanisms of disease and prospective epidemiological studies.
引用
收藏
页码:580 / 587
页数:8
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