Enantioselective Synthesis of (-)-Basiliskamide A

被引：11

作者：

Chen, Ming ^{[1
]}

Roush, William R. ^{[1
]}

机构：

[1] Scripps Florida, Dept Chem, Jupiter, FL 33458 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PD/C-CATALYZED HYDROGENATION; BASILISKAMIDE-B; COUPLING REACTIONS; DEPROTECTION; CONVERSION; ALDEHYDES; REAGENTS; ALCOHOLS; ETHERS; ESTER;

D O I：

10.1021/ol300282e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available beta-hydroxy ester 7. The synthesis features a highly diastereoselective mismatched double asymmetric delta-stannylallylboration reaction of aldehyde 5 with the bifunctional allylborane reagent 4.

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收藏

页码：1556 / 1559

页数：4

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