Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities

被引：2

作者：

Nomoto, Akihiro ^{[1
]}

Sakamoto, Nozomi ^{[1
]}

Sakai, Yuta ^{[1
]}

Fukumoto, Keisuke ^{[1
]}

Ogura, Shun-Ichiro ^{[2
]}

Shouhei, Katao ^{[3
]}

Kakiuchi, Kiyomi ^{[3
]}

Kikuchi, Jun-ichi ^{[3
]}

Yano, Shigenobu ^{[3
]}

Ogawa, Akiya ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Dept Appl Chem, Grad Sch Engn, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan

[2] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Midori Ku, 4259 B47 Nagatsutacho, Yokohama, Kanagawa 2268501, Japan

[3] Nara Inst Sci & Technol NAIST, Grad Sch Mat Sci, 8916-5 Takayama, Nara 6300192, Japan

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 01期

关键词：

Phenylalanine; Schiff base; Crystal structure; Palladium(II) complex; Platinum(II) complex; AMINO-ACID; ANTITUMOR-ACTIVITY; CANCER; LIGANDS;

D O I：

10.1007/s11164-018-3623-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex.

引用

页码：3 / 12

页数：10

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