Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities

被引：2
|
作者：
Nomoto, Akihiro [1 ]
Sakamoto, Nozomi [1 ]
Sakai, Yuta [1 ]
Fukumoto, Keisuke [1 ]
Ogura, Shun-Ichiro [2 ]
Shouhei, Katao [3 ]
Kakiuchi, Kiyomi [3 ]
Kikuchi, Jun-ichi [3 ]
Yano, Shigenobu [3 ]
Ogawa, Akiya [1 ]
机构：
[1] Osaka Prefecture Univ, Dept Appl Chem, Grad Sch Engn, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan
[2] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Midori Ku, 4259 B47 Nagatsutacho, Yokohama, Kanagawa 2268501, Japan
[3] Nara Inst Sci & Technol NAIST, Grad Sch Mat Sci, 8916-5 Takayama, Nara 6300192, Japan
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 01期
关键词：
Phenylalanine; Schiff base; Crystal structure; Palladium(II) complex; Platinum(II) complex; AMINO-ACID; ANTITUMOR-ACTIVITY; CANCER; LIGANDS;
D O I：
10.1007/s11164-018-3623-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex.
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页码：3 / 12
页数：10
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