Direct synthesis of methyl phosphoramidates in carbohydrates

被引：8
作者：
Dhurandhare, Vijay M. [1 ,2 ,3 ]
Mishra, Girija Prasad [1 ,4 ]
Lam, Sarah [1 ]
Wang, Cheng-Chung [1 ,2 ]
机构：
[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan
[2] Taiwan Int Grad Program, Chem Biol & Mol Biophys, Taipei, Taiwan
[3] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan
[4] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 36期
关键词：
CAMPYLOBACTER-JEJUNI; ANALOGS; CAPSULE;
D O I：
10.1039/c5ob01017a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct installation of a methyl phosphoramidate group by using methyl benzylphosphoramidochloridate into carbohydrates and amino acid is described. This one-step synthesis is efficient for both primary and secondary alcohols and exhibited excellent regioselectivity and functional group compatibility. Formation of a single diastereomer is observed in certain cases. The N-benzyl protecting group on methyl phosphoramidates is easily removed under mild conditions.
引用
收藏
页码：9457 / 9461
页数：5
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