RNA structure: Reading the ribosome

被引:267
作者
Noller, HF [1 ]
机构
[1] Univ Calif Santa Cruz, Sinsheimer Labs, Dept Mol Cell & Dev Biol, Ctr Mol Biol RNA, Santa Cruz, CA 95064 USA
关键词
D O I
10.1126/science.1111771
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The crystal structures of the ribosome and its subunits have increased the amount of information about RNA structure by about two orders of magnitude. This is leading to an understanding of the principles of RNA folding and of the molecular interactions that underlie the functional capabilities of the ribosome and other RNA systems. Nearly all of the possible types of RNA tertiary interactions have been found in ribosomal RNA. One of these, an abundant tertiary structural motif called the A-minor interaction, has been shown to participate in both aminoacyl-transfer RNA selection and in peptidyl transferase; it may also play an important role in the structural dynamics of the ribosome.
引用
收藏
页码:1508 / 1514
页数:7
相关论文
共 67 条
  • [61] THE CONFORMATION OF THE SARCIN RICIN LOOP FROM 28S RIBOSOMAL-RNA
    SZEWCZAK, AA
    MOORE, PB
    CHAN, YL
    WOOL, IG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) : 9581 - 9585
  • [62] RNA structure comes of age
    Uhlenbeck, OC
    Pardi, A
    Feigon, J
    [J]. CELL, 1997, 90 (05) : 833 - 840
  • [63] Locking and unlocking of ribosomal motions
    Valle, M
    Zavialov, A
    Sengupta, J
    Rawat, U
    Ehrenberg, M
    Frank, J
    [J]. CELL, 2003, 114 (01) : 123 - 134
  • [64] Structure of the 30S ribosomal subunit
    Wimberly B.T.
    Brodersen D.E.
    Clemons Jr. W.M.
    Morgan-Warren R.J.
    Carter A.P.
    Vonrheln C.
    Hartsch T.
    Ramakrishnan V.
    [J]. Nature, 2000, 407 (6802) : 327 - 339
  • [65] SECONDARY STRUCTURE MODEL FOR BACTERIAL 16S RIBOSOMAL-RNA - PHYLOGENETIC, ENZYMATIC AND CHEMICAL EVIDENCE
    WOESE, CR
    MAGRUM, LJ
    GUPTA, R
    SIEGEL, RB
    STAHL, DA
    KOP, J
    CRAWFORD, N
    BROSIUS, J
    GUTELL, R
    HOGAN, JJ
    NOLLER, HF
    [J]. NUCLEIC ACIDS RESEARCH, 1980, 8 (10) : 2275 - 2293
  • [66] ARCHITECTURE OF RIBOSOMAL-RNA - CONSTRAINTS ON THE SEQUENCE OF TETRA-LOOPS
    WOESE, CR
    WINKER, S
    GUTELL, RR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) : 8467 - 8471
  • [67] Crystal structure of the ribosome at 5.5 Å resolution
    Yusupov, MM
    Yusupova, GZ
    Baucom, A
    Lieberman, K
    Earnest, TN
    Cate, JHD
    Noller, HF
    [J]. SCIENCE, 2001, 292 (5518) : 883 - 896