There Is No Simple Model of the Plasma Membrane Organizationyy

被引：118

作者：

de la Serna, Jorge Bernardino ^{[1
]}

Schuetz, Gerhard J. ^{[2
]}

Eggeling, Christian ^{[3
]}

Cebecauer, Marek ^{[4
]}

机构：

[1] Rutherford Appleton Lab, Cent Laser Facil, Sci & Technol Facil Council, Res Complex Harwell, Harwell, Berks, England

[2] Tech Univ Wien, Inst Appl Phys, Vienna, Austria

[3] Univ Oxford, MRC Human Immunol Unit, Weatherall Inst Mol Med, Headley Way, Oxford, England

[4] Czech Acad Sci, Dept Biophys Chem, J Heyrovsky Inst Phys Chem, Prague, Czech Republic

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2016年 / 4卷

基金：

奥地利科学基金会; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

plasma membrane; membrane organization models; nanodomains; heterogenous distribution; membrane physical properties; SINGLE-MOLECULE TRACKING; LIPID-PROTEIN INTERACTIONS; LIVING CELL-MEMBRANE; FLUID-MOSAIC MODEL; FC-EPSILON-RI; LATERAL DIFFUSION; CORTICAL ACTIN; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; CORRELATION SPECTROSCOPY; PHOTOBLEACHING RECOVERY;

D O I：

10.3389/fcell.2016.00106

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure.

引用

页数：17