Heme oxygenase: A target gene for anti-diabetic and obesity

被引：52
作者：
Abraham, N. G. [1 ]
Tsenovoy, P. L. [1 ]
McClung, J. [1 ]
Drummond, G. S. [1 ]
机构：
[1] New York Med Coll, Valhalla, NY 10595 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2008年 / 14卷 / 05期
关键词：
diabetes; carbon monoxide; bilirubin; HO-1; inflamation; TNF; IL-1; adiponectin;
D O I：
10.2174/138161208783597371
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.
引用
收藏
页码：412 / 421
页数：10
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