Bariatric Surgery for Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy: a Matched Case-Control Study

被引：9
作者：
Garrez, Ieme [1 ]
Lapauw, Bruno [2 ]
Van Nieuwenhove, Yves [3 ]
机构：
[1] Univ Ghent, Fac Med & Hlth Sci, De Pintelaan 185, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Dept Endocrinol, De Pintelaan 185, B-9000 Ghent, Belgium
[3] Ghent Univ Hosp, Dept Gastrointestinal Surg, De Pintelaan 185, B-9000 Ghent, Belgium
来源：
OBESITY SURGERY | 2020年 / 30卷 / 06期
关键词：
Craniopharyngioma; Hypothalamic obesity; Bariatric surgery; Sleeve gastrectomy; Roux-en-Y gastric bypass; Hormone substitution; GASTRIC BYPASS-SURGERY; REPLACEMENT THERAPY; WEIGHT-LOSS; MORTALITY; DAMAGE; RISK;
D O I：
10.1007/s11695-020-04391-w
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Craniopharyngioma and its treatment lead to weight gain and pituitary hormone deficiencies. This study aimed to investigate the effectiveness of bariatric surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. Five patients with hypothalamic obesity after craniopharyngioma treatment were included. Patients were treated with sleeve gastrectomy or Roux-en-Y gastric bypass and individually matched to 2 control patients treated for common obesity. At 2 years of follow-up, total and excess weight loss in cases were 14.7% (p = 0.002) and 38.0% (p = 0.001), respectively; differences between both groups were 13.6% (p = 0.02) and 31.6% (p = 0.03). Minor postoperative alterations in hormone substitution in all 5 cases were observed. Thus, bariatric surgery induced significant weight loss in patients with craniopharyngioma-related hypothalamic obesity, even though a superior weight loss in controls was observed.
引用
收藏
页码：2439 / 2444
页数：6
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