Cytotoxic triterpenoids from the root bark of Helicteres angustifolia

被引：28
作者：
Pan, Min-Hsiung [3 ]
Chen, Chiu-Ming [2 ]
Lee, Shwu-Woan [1 ]
Chen, Zong-Tsi [1 ]
机构：
[1] Chia Nan Univ Pharm & Sci, Dept Appl Chem, Tainan 717, Taiwan
[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan
[3] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung 811, Taiwan
来源：
CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 04期
关键词：
D O I：
10.1002/cbdv.200890053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new triterpenoids, 3 beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3 beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3 beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 412, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3 beta-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.
引用
收藏
页码：565 / 574
页数：10
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