Cytotoxic triterpenoids from the root bark of Helicteres angustifolia

被引：28

作者：

Pan, Min-Hsiung ^{[3
]}

Chen, Chiu-Ming ^{[2
]}

Lee, Shwu-Woan ^{[1
]}

Chen, Zong-Tsi ^{[1
]}

机构：

[1] Chia Nan Univ Pharm & Sci, Dept Appl Chem, Tainan 717, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

[3] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung 811, Taiwan

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 04期

关键词：

D O I：

10.1002/cbdv.200890053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new triterpenoids, 3 beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3 beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3 beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 412, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3 beta-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.

引用

页码：565 / 574

页数：10

共 50 条

[1] New triterpenoids from Helicteres angustifolia
Guo, XD
An, LK
Xu, D
Ma, L
Gu, LQ
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2003, 24 (11): : 2022 - 2023
[2] Cytotoxic triterpenoids from the stem bark ofAglaia angustifolia
Hutagaol, Ricson Pemimpin
Harneti, Desi
Safari, Agus
Hidayat, Ace Tatang
Supratman, Unang
Awang, Khalijah
Shiono, Yoshihito
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 23 (08) : 781 - 788
[3] Cytotoxic effect of triterpenoids from the root bark of Hibiscus syriacus
Shi, Li-Shian
Wu, Chao-Hsuan
Yang, Te-Chun
Yao, Chen-Wen
Lin, Hang-Ching
Chang, Wen-Liang
FITOTERAPIA, 2014, 97 : 184 - 191
[4] Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia
Chen, Zong-Tsi
Lee, Shwu-Woan
Chen, Chiu-Ming
CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (11) : 1605 - 1607
[5] Antidiabetic activity of Helicteres angustifolia root
Hu, Xuansheng
Cheng, Delin
Zhang, Zhenya
PHARMACEUTICAL BIOLOGY, 2016, 54 (06) : 938 - 944
[6] Potentially Cytotoxic Triterpenoids from the Root Bark of Siphonodon celastrineus Griff.
Chokchai Niampoka
Rutt Suttisri
Rapepol Bavovada
Hiromitsu Takayama
Norio Aimi
Archives of Pharmacal Research, 2005, 28 : 546 - 549
[7] Potentially cytotoxic triterpenoids from the root bark of Siphonodon celastrineus griff.
Niampoka, C
Suttisri, R
Bavovada, R
Takayama, H
Aimi, N
ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (05) : 546 - 549
[8] Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia
Chen, Wenliang
Tang, Weidong
Lou, Liguang
Zhao, Weimin
PHYTOCHEMISTRY, 2006, 67 (10) : 1041 - 1047
[9] Triterpenoids from Calotropis procera root bark
Gupta, DK
Ali, M
Bhutani, KK
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1996, 35 (10): : 1079 - 1084
[10] Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
Harneti, Desi
Tjokronegoro, Roekmiati
Safari, Agus
Supratman, Unang
Loong, Xe-Min
Mukhtar, Mat Ropi
Mohamad, Khalit
Awang, Khalijah
Hayashi, Hideo
PHYTOCHEMISTRY LETTERS, 2012, 5 (03) : 496 - 499

← 1 2 3 4 5 →