HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART

被引：190

作者：

Ananworanich, Jintanat ^{[1
,2
,3
,4
]}

Chomont, Nicolas ^{[5
,6
]}

Eller, Leigh Ann ^{[1
,2
]}

Kroon, Eugene ^{[3
,4
]}

Tovanabutra, Sodsai ^{[1
,2
]}

Bose, Meera ^{[1
,2
]}

Nau, Martin ^{[1
,2
]}

Fletcher, James L. K. ^{[3
,4
]}

Tipsuk, Somporn ^{[3
,4
]}

Vandergeeten, Claire ^{[6
]}

O'Connell, Robert J. ^{[5
]}

Pinyakorn, Suteeraporn ^{[1
,2
]}

Michael, Nelson ^{[1
]}

Phanuphak, Nittaya ^{[3
,4
]}

Robb, Merlin L. ^{[1
,2
]}

机构：

[1] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA

[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA

[3] Armed Forces Res Inst Med Sci, Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand

[4] Univ Montreal, CRCHUM, Montreal, PQ, Canada

[5] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada

[6] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA

来源：

EBIOMEDICINE | 2016年 / 11卷

关键词：

Acute HIV infection; Art; HIV DNA; Reservoir; Persistence; CD4 CELL COUNT; ANTIRETROVIRAL THERAPY; DISEASE PROGRESSION; LATENT RESERVOIR; SIZE; REMISSION; IMPACT; LEVEL; DECAY; CURE;

D O I：

10.1016/j.ebiom.2016.07.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM -) stage, that is <= 2 weeks from infection. Without antiretroviral therapy (ART), HIV DNA peaked at 2 weeks after enrollment, reaching a set-point 2 weeks later with little change thereafter. There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2 weeks and 316-fold after 3 years. Therefore, very early ART offers the opportunity to significantly reduce the frequency of cells harboring HIV DNA. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：68 / 72

页数：5

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