Cellular Metabolism and Aging

被引：27

作者：

Catic, Andre ^{[1
]}

机构：

[1] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Huffington Ctr Aging, Stem Cells & Regenerat Med Ctr, Houston, TX 77030 USA

来源：

METABOLIC ASPECTS OF AGING | 2018年 / 155卷

关键词：

LIFE-SPAN EXTENSION; TRANSGENERATIONAL EPIGENETIC INHERITANCE; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; GLYCINE SUPPLEMENTATION; INCREASING GLUTATHIONE; SIGNALING MOLECULES; HISTONE ACETYLATION; RESPIRATORY-CHAIN; NAD(+) METABOLISM;

D O I：

10.1016/bs.pmbts.2017.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this review, we will outline how cellular biochemistry and energy homeostasis change during aging. We will highlight protein quality control, mitochondria, epigenetics, nutrient-sensing pathways, as well as the interplay between these systems with respect to their impact on cellular health.

引用

页码：85 / 107

页数：23

共 133 条

[1] The mitochondrial respiratory chain is essential for haematopoietic stem cell function [J].

Anso, Elena ;

Weinberg, Samuel E. ;

Diebold, Lauren P. ;

Thompson, Benjamin J. ;

Malinge, Sebastien ;

Schumacker, Paul T. ;

Liu, Xin ;

Zhang, Yuannyu ;

Shao, Zhen ;

Steadman, Mya ;

Marsh, Kelly M. ;

Xu, Jian ;

Crispino, John D. ;

Chandel, Navdeep S. .

NATURE CELL BIOLOGY, 2017, 19 (06) :614-+

[2] Aging as an Epigenetic Phenomenon [J].

Ashapkin, Vasily V. ;

Kutueva, Lyudmila I. ;

Vanyushin, Boris F. .

CURRENT GENOMICS, 2017, 18 (05) :385-407

[3] Increased cell-to-cell variation in gene expression in ageing mouse heart [J].

Bahar, Rumana ;

Hartmann, Claudia H. ;

Rodriguez, Karl A. ;

Denny, Ashley D. ;

Busuttil, Rita A. ;

Dolle, Martijn E. T. ;

Calder, R. Brent ;

Chisholm, Gary B. ;

Pollock, Brad H. ;

Klein, Christoph A. ;

Vijg, Jan .

NATURE, 2006, 441 (7096) :1011-1014

[4] In vivo aspects of protein folding and quality control [J].

Balchin, David ;

Hayer-Hartl, Manajit ;

Hartl, F. Ulrich .

SCIENCE, 2016, 353 (6294)

[5] The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation? [J].

Bennett, Christopher F. ;

Kaeberlein, Matt .

EXPERIMENTAL GERONTOLOGY, 2014, 56 :142-146

[6] Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster [J].

Bjedov, Ivana ;

Toivonen, Janne M. ;

Kerr, Fiona ;

Slack, Cathy ;

Jacobson, Jake ;

Foley, Andrea ;

Partridge, Linda .

CELL METABOLISM, 2010, 11 (01) :35-46

[7] Mitochondrial genomes are retained by selective constraints on protein targeting [J].

Bjorkholm, Patrik ;

Harish, Ajith ;

Hagstrom, Erik ;

Ernst, Andreas M. ;

Andersson, Siv G. E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (33) :10154-10161

[8] The role of mitochondria in aging [J].

Bratic, Ana ;

Larsson, Nils-Goran .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03) :951-957

[9] A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease [J].

Brehme, Marc ;

Voisine, Cindy ;

Rolland, Thomas ;

Wachi, Shinichiro ;

Soper, James H. ;

Zhu, Yitan ;

Orton, Kai ;

Villella, Adriana ;

Garza, Dan ;

Vidal, Marc ;

Ge, Hui ;

Morimoto, Richard I. .

CELL REPORTS, 2014, 9 (03) :1135-1150

[10] Interaction between epigenetic and metabolism in aging stem cells [J].

Brunet, Anne ;

Rando, Thomas A. .

CURRENT OPINION IN CELL BIOLOGY, 2017, 45 :1-7

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