The Rho GTPases have multiple effects on the actin cytoskeleton

被引：107

作者：

Aspenström, P ^{[1
]}

机构：

[1] Biomed Ctr, Ludwig Inst Canc Res, S-75124 Uppsala, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 1999年 / 246卷 / 01期

关键词：

D O I：

10.1006/excr.1998.4300

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The importance for the Rho GTPases Rho, Rac, and Cdc42 for the heterogeneity of the actin cytoskeleton is well documented. However, there is now an emerging view that they also have important roles in signaling pathways that control gene transcription, cell cycle regulation, apoptosis, and tumor progression. Furthermore, not only has the number of pathways which involve Rho GTPases increased, the number of Rho family members and their regulating proteins has increased considerably. This raises important questions regarding how specificity is achieved in cell signaling employing Rho GTPases. (C) 1999 Academic Press.

引用

页码：20 / 25

页数：6

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