Entrainment of a Population of Synthetic Genetic Oscillators

被引：140

作者：

Mondragon-Palomino, Octavio ^{[1
]}

Danino, Tal ^{[1
]}

Selimkhanov, Jangir ^{[1
,2
]}

Tsimring, Lev ^{[2
,4
]}

Hasty, Jeff ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, San Diego Ctr Syst Biol, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, BioCircuits Inst, La Jolla, CA 92093 USA

来源：

SCIENCE | 2011年 / 333卷 / 6047期

基金：

美国国家卫生研究院;

关键词：

REVEALS PERSISTENT; CIRCADIAN-RHYTHMS; CLOCKS; EXPRESSION; CIRCUITS; BIOLOGY; DESIGN; SYSTEM; LIGHT;

D O I：

10.1126/science.1205369

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biological clocks are self-sustained oscillators that adjust their phase to the daily environmental cycles in a process known as entrainment. Molecular dissection and mathematical modeling of biological oscillators have progressed quite far, but quantitative insights on the entrainment of clocks are relatively sparse. We simultaneously tracked the phases of hundreds of synthetic genetic oscillators relative to a common external stimulus to map the entrainment regions predicted by a detailed model of the clock. Synthetic oscillators were frequency-locked in wide intervals of the external period and showed higher-order resonance. Computational simulations indicated that natural oscillators may contain a positive-feedback loop to robustly adapt to environmental cycles.

引用

页码：1315 / 1319

页数：5

共 29 条

[1] Coupling governs entrainment range of circadian clocks [J].

Abraham, Ute ;

Granada, Adrian E. ;

Westermark, Pal O. ;

Heine, Markus ;

Kramer, Achim ;

Herzel, Hanspeter .

MOLECULAR SYSTEMS BIOLOGY, 2010, 6

[2] A synthetic multicellular system for programmed pattern formation [J].

Basu, S ;

Gerchman, Y ;

Collins, CH ;

Arnold, FH ;

Weiss, R .

NATURE, 2005, 434 (7037) :1130-1134

[3] Circadian rhythms from multiple oscillators: Lessons from diverse organisms [J].

Bell-Pedersen, D ;

Cassone, VM ;

Earnest, DJ ;

Golden, SS ;

Hardin, PE ;

Thomas, TL ;

Zoran, MJ .

NATURE REVIEWS GENETICS, 2005, 6 (07) :544-556

[4] Integration of light and temperature in the regulation of circadian gene expression in Drosophila [J].

Boothroyd, Catharine E. ;

Wijnen, Herman ;

Naef, Felix ;

Saez, Lino ;

Young, Michael W. .

PLOS GENETICS, 2007, 3 (04) :0492-0507

[5] Imaging of single light-responsive clock cells reveals fluctuating free-running periods [J].

Carr, AJF ;

Whitmore, D .

NATURE CELL BIOLOGY, 2005, 7 (03) :319-U127

[6] A synchronized quorum of genetic clocks [J].

Danino, Tal ;

Mondragon-Palomino, Octavio ;

Tsimring, Lev ;

Hasty, Jeff .

NATURE, 2010, 463 (7279) :326-330

[7] The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks [J].

Dibner, Charna ;

Schibler, Ueli ;

Albrecht, Urs .

ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 :517-549

[8] A synthetic oscillatory network of transcriptional regulators [J].

Elowitz, MB ;

Leibler, S .

NATURE, 2000, 403 (6767) :335-338

[9] Foundations for engineering biology [J].

Endy, D .

NATURE, 2005, 438 (7067) :449-453

[10] Intra- and intercellular fluctuations in Min-protein dynamics decrease with cell length [J].

Fischer-Friedrich, Elisabeth ;

Meacci, Giovanni ;

Lutkenhaus, Joe ;

Chate, Hugues ;

Kruse, Karsten .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) :6134-6139

← 1 2 3 →