Elevated SP/NK-1R in esophageal carcinoma promotes esophageal carcinoma cell proliferation and migration

被引：27

作者：

Dong, Jiaqiang ^{[1
]}

Feng, Fan ^{[1
]}

Xu, Guanghui ^{[1
]}

Zhang, Hongwei ^{[1
]}

Hong, Liu ^{[1
]}

Yang, Jianjun ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China

来源：

GENE | 2015年 / 560卷 / 02期

关键词：

Esophageal squamous cell carcinoma; Substance P; NK-1R; Proliferation; Migration; HUMAN ASTROCYTOMA-CELLS; SUBSTANCE-P RECEPTORS; NK-1; RECEPTOR; CANCER; TUMOR; ANTAGONISTS; EXPRESSION; GROWTH;

D O I：

10.1016/j.gene.2015.02.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal malignant tumors, and currently there is no effective ways to manage the late stage disease. Therefore clarifying the mechanisms underlying the development of ESCC is of great importance to develop novel therapeutic agents. The present study focuses on the interaction between neurotransmitter substance P (SP) together with its receptor NK-1R and ESCC progression. Methods: The distribution of SP positive nerve fibers and expression of NK-1R were detected in ESCC tissue using immunohistochemistry. The effects of SP stimulation and blocking on the growth and migration of ESCC cells were measured by in vitro and in vivo assay. Results: A higher density of SP positive nerve fibers and elevated NK-1R expression on ESCC cells were observed. More importantly, the SP positive fiber density was correlated with tumor size and lymph node metastasis. SP promoted ESCC cell proliferation and migration by modulation of intracellular calcium levels. Conclusion: NK-1R activation by SP stimulation promotes growth and migration of ESCC cells. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：205 / 210

页数：6

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