Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma

被引：3

作者：

Gadage, Vijaya S. ^{[1
]}

Subramanian, P. G. ^{[1
]}

Galani, Komal S. ^{[1
]}

Sehgal, Kunal K. ^{[1
]}

Johari, Sachin P. ^{[1
]}

Ghogale, Vijay S. ^{[1
]}

Badrinath, Y. ^{[1
]}

Ashok, K. ^{[1
]}

Gujral, Sumeet ^{[1
]}

机构：

[1] Tata Mem Hosp, Hematopathol Lab, Bombay 400012, Maharashtra, India

来源：

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY | 2011年 / 54卷 / 03期

关键词：

Anaplastic large cell lymphoma; flow cytometry; leukemic phase; OF-THE-LITERATURE;

D O I：

10.4103/0377-4929.85108

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.

引用

页码：599 / 602

页数：4

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