Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

被引:105
作者
Ferrando, AA
Neuberg, DS
Dodge, RK
Paietta, E
Larson, RA
Wiernik, PH
Rowe, JM
Caligiuri, MA
Bloomfield, CD
Look, AT
机构
[1] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat Sci, Boston, MA 02115 USA
[3] Our Lady Mercy Med Ctr, Eastern Cooperat Oncol Grp, Bronx, NY USA
[4] Duke Univ, Med Ctr, Canc & Leukemia Grp B, Durham, NC 27706 USA
[5] Univ Chicago, Chicago, IL 60637 USA
[6] Rambam Med Ctr, Dept Hematol & BMT, Haifa, Israel
[7] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
关键词
D O I
10.1016/S0140-6736(04)15542-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic. relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors-TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2-in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.
引用
收藏
页码:535 / 536
页数:2
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