Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis:: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis

被引:5
作者
Narahara, H [1 ]
Tatsuta, M [1 ]
Iishi, H [1 ]
Baba, M [1 ]
Mikuni, T [1 ]
Uedo, N [1 ]
Sakai, N [1 ]
Yano, H [1 ]
机构
[1] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol, Higashinari Ku, Osaka 5378511, Japan
关键词
ambroxol; gastric carcinogenesis; monochloramine; N-methyl-N '-nitro-N-nitrosoguanidine; Helicobacter pylori;
D O I
10.1016/S0304-3835(01)00495-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effects of combined administration of a reactive oxidant, monochloramine, and a mucoregulatory agent, ambroxol, on the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in inbred Wistar rats. After receiving oral MNNG and regular chow pellets for 25 weeks, rats received regular chow pellets or chow pellets containing 20% ammonium acetate, and normal tap water or water containing 30 mM sodium hypochlorite, with or without subcutaneous injection of ambroxol at high or low doses, until the end of the experiment at week 52. Treatment with both ammonium acetate and sodium hypochlorite, which produce monochloramine, significantly increased the incidence of gastric cancers at week 52, whereas concomitant administration of ambroxol with ammonium acetate and sodium hypochlorite significantly attenuated this enhanced gastric carcinogenesis. Results also revealed that ambroxol scavenged monochloramine. Because monochloramine is closely related to Helicobacter pylori-associated gastric carcinogenesis, these findings suggest that ambroxol may prevent H, pylori-associated gastric carcinogenesis. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.
引用
收藏
页码:117 / 124
页数:8
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