Curvulin and spirostaphylotrichins R and U from extracts produced by two endophytic Bipolaris sp. associated to aquatic macrophytes with antileishmanial activity

被引：15

作者：

de Almeida, Tiago Tognolli ^{[1
,2
]}

dos Santos Ribeiro, Marcos Alessandro ^{[1
,3
]}

Polonio, Julio Cesar ^{[1
]}

Garcia, Francielle Pelegrin ^{[4
]}

Nakamura, Celso Vataru ^{[4
]}

Meurer, Eduardo Cesar ^{[5
]}

Sarragiotto, Maria Helena ^{[3
]}

Baldoqui, Debora Cristina ^{[3
]}

Azevedo, Joao Lucio ^{[6
]}

Pamphile, Joao Alencar ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Biotecnol Genet & Biol Celular, Maringa, Parana, Brazil

[2] Univ Sao Paulo, CENA, Piracicaba, Brazil

[3] Univ Estadual Maringa, Dept Quim, Maringa, Parana, Brazil

[4] Univ Estadual Maringa, Lab Inovacao Tecnol Desenvolvimento Farmacos & Co, Programa Posgrad Ciencias Biol, Maringa, Parana, Brazil

[5] Univ Fed Parana, Fenn Mass Spectrometry Lab, Jandaia Do Sul, Brazil

[6] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Genet, Piracicaba, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 23期

关键词：

Eichhornia azurea; Eichhornia crassipes; endophytes; MS/MS fragmentation mechanism; FUNGI; DIVERSITY; KUNTH;

D O I：

10.1080/14786419.2017.1380011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present study, biological activity and chemical composition of two crude extracts of endophytic fungal strains of Bipolaris genera isolated from two species of aquatic macrophytes: Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.) were investigated. The nuclear magnetic resonance and mass spectrometry data provided the identification of three main compounds: curvulin (1), spirostaphylotrichin R (2) and U (3). The fragmentation mechanism of the precursor ions towards collision induced dissociation (CID) tandem mass spectrometry experiment (MS/MS) is also proposed. Furthermore, biological screening of the crude extracts displayed antileishmanial activity with IC 50 values ranging from 70-84.2 mu g. mL(-1). [GRAPHICS] .

引用

页码：2783 / 2790

页数：8

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