A digital acoustofluidic device for on-demand and oil-free droplet generation

被引：24

作者：

Chen, Keke ^{[1
]}

Sui, Chenxi ^{[1
]}

Wu, Yue ^{[2
]}

Ao, Zheng ^{[2
]}

Guo, Shi-Shang ^{[1
]}

Guo, Feng ^{[2
]}

机构：

[1] Wuhan Univ, Minist Educ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Wuhan 430072, Hubei, Peoples R China

[2] Indiana Univ, Dept Intelligent Syst Engn, Bloomington, IN 47405 USA

来源：

NANOTECHNOLOGY | 2019年 / 30卷 / 08期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

microfluidics; surface acoustic wave; acoustofluidics; droplet; PICOLITER DROPLETS; CELLS; CHIP; MICROFLUIDICS; SEPARATION; DYNAMICS; SYSTEM;

D O I：

10.1088/1361-6528/aaf3fd

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We report a digital acoustofluidic device for on-demand and oil-free droplet generation. By applying a programmed radio frequency signal to a circular interdigital transducer, the dynamic focused acoustic pressure profiles generated rise up and dispense sample liquids from a reservoir to dynamically eject the droplets into the air. Our device allows droplets to be dispensed on demand with precisely controlled generation time and sequence, and accurate droplet volume. Moreover, we also demonstrate the generation of a droplet with a volume of 24 pL within 10 ms, as well as the encapsulation of a single cell into droplets. This acoustofluidic droplet generation technique is simple, biocompatible, and enables the on-demand droplet generation and encapsulation of many different biological materials with precise control, which is promising for single cell sampling and analysis applications.

引用

页数：7

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