NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone

被引：57

作者：

Esensten, JH ^{[1
]}

Tsytsykova, AV ^{[1
]}

Lopez-Rodriguez, C ^{[1
]}

Ligeiro, FA ^{[1
]}

Rao, A ^{[1
]}

Goldfeld, AE ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, CBR Inst Biomed Res, Boston, MA 02115 USA

来源：

NUCLEIC ACIDS RESEARCH | 2005年 / 33卷 / 12期

关键词：

D O I：

10.1093/nar/gki701

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structures or enhanceosomes. NFATp, a member of the nuclear factor of activated T cells (NFAT) family of transcription factors, plays a critical role in TNF gene regulation under a variety of conditions. In this study, we show that NFAT5, the most recently described NFAT family member, binds to the TNF promoter in a manner distinct from other NFAT proteins and is a key mediator in the activation of TNF gene transcription during hypertonic stress alone.

引用

页码：3845 / 3854

页数：10

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