Microtubule dynamics regulated by stathmin

被引：9

作者：

Budhachandra, Kh. ^{[2
]}

Singh, R. K. Brojen ^{[1
,3
]}

Menon, G. I. ^{[4
]}

机构：

[1] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India

[2] Natl Brain Res Ctr, Computat Neurosci & Neuroimaging Lab, Manesar 122050, Gurgaon, India

[3] Jawaharlal Nehru Univ, Sch Informat Technol, Ctr Computat Biol & Bioinformat, New Delhi 110067, India

[4] Inst Math Sci, Madras 600113, Tamil Nadu, India

来源：

COMPUTATIONAL BIOLOGY AND CHEMISTRY | 2008年 / 32卷 / 02期

关键词：

stathmin; Monte Carlo; gradient region; catastrophe; rescue; tubulin;

D O I：

10.1016/j.compbiolchem.2007.12.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microtubles perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin-tubulin interaction gradients. Computer simulation of the model with stathmin-tublin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin-tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：141 / 144

页数：4

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