Three-component one-pot total syntheses of glyantrypine, fumiquinazoline F, and fiscalin B promoted by microwave irradiation

被引：94

作者：

Liu, JF ^{[1
]}

Ye, P ^{[1
]}

Zhang, BL ^{[1
]}

Bi, G ^{[1
]}

Sargent, K ^{[1
]}

Yu, LB ^{[1
]}

Yohannes, D ^{[1
]}

Baldino, CM ^{[1
]}

机构：

[1] ArQule Inc, Div Chem Technol, Woburn, MA 01801 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo0508043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-promoted three-component one-pot reaction has been developed to provide access to the core pyrazino[2,1-b]quinazoline-3,6-dione (1) scaffold, which is common to several families of alkaloids with significant biological activities. By adapting this synthetic strategy through the use of selected Boc-amino acids and amino acid esters, we have accomplished highly efficient and concise total syntheses of glyantrypine (2), fumiquinazoline F (3), and fiscalin B (5), achieving overall yields of 55, 39, and 20%, respectively.

引用

页码：6339 / 6345

页数：7

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