Effects of sildenafil on the viability of random skin flaps

被引：20

作者：

Barral, Sumara Marques ^{[1
,2
]}

Araujo, Ivana Duval

Teixeira Vidigal, Paula Vieira ^{[3
]}

Campos Mayrink, Claudio Alvarenga ^{[4
]}

Araujo, Adriana Duval

da Costa, Paulo Roberto ^{[5
]}

机构：

[1] Univ Fed Minas Gerais, Anim Experimentat Lab, Dept Surg, Fac Med, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Volunteer Fac, Dept Surg, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2011年 / 26卷 / 04期

关键词：

Wound Healing; Surgical Flaps; Cyclic GMP; Nitric Oxide; Rats; SURVIVAL; RATS; PENTOXIFYLLINE; CITRATE;

D O I：

10.1590/S0102-86502011000400012

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose: To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. Methods: Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis. Results: Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil. Conclusion: Sildenafil subdermally was associated with lower viability of the random skin flap in rats.

引用

页码：314 / 319

页数：6

共 15 条

[1] Effect of sildenafil citrate on viability of flaps:: An experimental study in rats [J].