Asymmetric Mukaiyama-Michael addition of acyclic enones catalyzed by allo-threonine-derived B-aryloxazaborolidinones

被引：33

作者：

Harada, T ^{[1
]}

Iwai, H ^{[1
]}

Takatsuki, H ^{[1
]}

Fujita, K ^{[1
]}

Kubo, M ^{[1
]}

Oku, A ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Chem, Sakyo Ku, Kyoto 6068585, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 13期

关键词：

D O I：

10.1021/ol016062r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] O-(2-Naphthoyl)-N-tosyl-L-allo-threonine B-phenyloxazaborolidinone catalyzes the asymmetric Mukaiyama-Michael addition of simple acyclic enones to give adducts of 54-85% ee, 2,6-Diisopropylphenal as an additive is demonstrated to effectively retard the undesirable Si+-catalyzed racemic pathway.

引用

页码：2101 / 2103

页数：3

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