TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1

被引：57

作者：

Triantafilou, K

Vakakis, E

Orthopoulos, G

Ahmed, MA

Schumann, C

Lepper, PM

Triantafilou, M ^{[1
]}

机构：

[1] Univ Sussex, Sch Life Sci, Infect & Immun Grp, Brighton BN1 9QG, E Sussex, England

[2] Univ Ulm, Dept Internal Med 2, D-7900 Ulm, Germany

[3] Ain Shams Univ, Fac Med, Dept Histol, Cairo, Egypt

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2005年 / 35卷 / 08期

关键词：

HPEV1; TLR; endosomes; TLR7; TLR8;

D O I：

10.1002/eji.200526149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.

引用

页码：2416 / 2423

页数：8

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