Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract

被引：31

作者：

Harput, US ^{[1
]}

Saracoglu, I

Ogihara, Y

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey

[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Pharmacognosy, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 04期

关键词：

Urtica dioica; Urticaceae; immunomodulation; antiinflammation; T-lymphocytes; nitric oxides; macrophages;

D O I：

10.1002/ptr.1686

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The immunomodulatory and antiinflammatory activities of aqueous Urtica dioica extract were investigated for their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that this extract stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide - stimulated macrophages without affecting cell viability. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：346 / 348

页数：3

共 11 条

[1] In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. [J].

Akbay, P ;

Basaran, AA ;

Undeger, U ;

Basaran, N .

PHYTOTHERAPY RESEARCH, 2003, 17 (01) :34-37

[2] Immunomodulatory effect of Tylophora indica on Con A induced lymphoproliferation [J].

Ganguly, T ;

Badheka, LP ;

Sainis, KB .

PHYTOMEDICINE, 2001, 8 (06) :431-437

[3] ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].

GREEN, LC ;

WAGNER, DA ;

GLOGOWSKI, J ;

SKIPPER, PL ;

WISHNOK, JS ;

TANNENBAUM, SR .

ANALYTICAL BIOCHEMISTRY, 1982, 126 (01) :131-138

[4] Anti-inflammatory and cytotoxic activities of five Veronica species [J].

Harput, US ;

Saracoglu, I ;

Inoue, M ;

Ogihara, Y .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2002, 25 (04) :483-486

[5] NITRIC-OXIDE SYNTHASES IN MAMMALS [J].

KNOWLES, RG ;

MONCADA, S .

BIOCHEMICAL JOURNAL, 1994, 298 :249-258

[6] Extracts from fruits of saw palmetto (Sabal serrulata) and roots of stinging nettle (Urtica dioica):: Viable alternatives in the medical treatment of benign prostatic hyperplasia and associated lower urinary tracts symptoms [J].

Koch, E .

PLANTA MEDICA, 2001, 67 (06) :489-500

[7] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[8] Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG) [J].

Schottner, M ;

Gansser, D ;

Spiteller, G .

PLANTA MEDICA, 1997, 63 (06) :529-532

[9] Effects of Astragali root and Hedysari root on the murine B and T cell differentiation [J].

Song, QH ;

Kobayashi, T ;

Xiu, LM ;

Hong, T ;

Cyong, JC .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :111-119

[10]

Terawaki K, 1997, BIOL PHARM BULL, V20, P435, DOI 10.1248/bpb.20.435

← 1 2 →