Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

被引：33

作者：

Nie, Ximing ^{[1
,2
]}

Wang, David ^{[3
]}

Pu, Yuehua ^{[1
,2
]}

Wei, Yufei ^{[1
,2
]}

Lu, Qixuan ^{[1
,2
]}

Yan, Hongyi ^{[1
,2
]}

Liu, Xin ^{[1
,2
]}

Zheng, Lina ^{[4
]}

Liu, Jingyi ^{[1
,2
]}

Yang, Xinxuan ^{[1
,2
]}

Ding, Yarong ^{[1
,2
]}

Liu, Dacheng ^{[1
,2
]}

Duan, Wanying ^{[1
,2
]}

Zhang, Zhe ^{[1
,2
]}

Yang, Zhonghua ^{[1
,2
]}

Wen, Miao ^{[1
,2
]}

Gu, Weibin ^{[5
]}

Hou, Xinyi ^{[5
]}

Leng, Xinyi ^{[4
]}

Pan, Yuesong ^{[1
,2
]}

Miao, Zhongrong ^{[6
]}

Liu, Liping ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China

[2] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China

[3] Barrow Neurol Inst, Dept Neurol, Neurovasc Div, Phoenix, AZ 85013 USA

[4] Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China

[5] Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China

[6] Capital Med Univ, Beijing Tiantan Hosp, Dept Intervent Neurol, Beijing, Peoples R China

来源：

STROKE AND VASCULAR NEUROLOGY | 2022年 / 7卷 / 03期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

stroke; thrombectomy; thrombolysis; TISSUE-PLASMINOGEN ACTIVATOR; ANTERIOR CIRCULATION STROKE; HEALTH-CARE PROFESSIONALS; HEMORRHAGIC TRANSFORMATION; EARLY MANAGEMENT; RECANALIZATION; THROMBECTOMY; THROMBOLYSIS; OUTCOMES; GUIDELINES;

D O I：

10.1136/svn-2021-001242

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose It remains controversial if endovascular treatment (EVT) can improve the outcome of patients with acute basilar artery occlusion (BAO). This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis (IVT) first in patients who had acute ischaemic stroke (AIS) due to BAO. Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study, and the efficacy and safety were compared between IVT+EVT and direct EVT. The primary outcome was 90-day functional independence. All outcomes were assessed with adjusted OR (aOR) from the multivariable logistic regression. In addition, a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO. Results Of 310 enrolled patients with BAO, 241 (78%) were treated with direct EVT and 69 (22%) with IVT+EVT. Direct EVT was associated with a worse functional outcome (aOR, 0.46 (95% CI 0.24 to 0.85), p=0.01). IVT+EVT was associated with a lower percentage of patients who needed >= 3 passes of stent retriever (10.14% vs 20.75%). The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence (r=0.14 (95% CI 0.05 to 0.24), p<0.01). Conclusions This study showed that compared with direct EVT, EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset. The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.

引用

页码：190 / 199

页数：10

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