Molecular processes in the streptokinase thrombolytic therapy

被引：10

作者：

Capitanescu, Cristian ^{[1
,2
]}

Oprescu, Anca Monica Macovei ^{[3
]}

Ionita, Dan ^{[4
]}

Dinca, Gabi Valeriu ^{[5
]}

Turculet, Claudiu ^{[3
]}

Manole, Gheorghe ^{[5
,6
]}

Macovei, Radu Alexandru ^{[3
]}

机构：

[1] SC Ecodet Activ SRL, Fizicienilor 22,BL-21A,Sc 1,Ap 22, Bucharest 3, Romania

[2] Natl Environm Protect Agcy, Splaiul Independentei 294, Bucharest 6, Romania

[3] Carol Davila Univ Med & Pharm, Dionisie Lupu 37, Bucharest 1, Romania

[4] Clin Hosp Grigore Alexandrescu, Iancu De Hunedoara 30-32, Bucharest 1, Romania

[5] Univ Titu Maiorescu, Gheorghe Petrascu 67A, Bucharest 3, Romania

[6] Clin Hosp Colentina, Stefan Cel Mare 19-21, Bucharest 2, Romania

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷 / 06期

关键词：

Antiplasmin; magnetic nanoparticle; streptokinase; thrombus; HUMAN PLASMINOGEN; SUBSTRATE; INHIBITOR; PLASMA;

D O I：

10.3109/14756366.2016.1142985

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectorized nanoparticles streptokinase and human blood thrombus. The experimental data confirm the maximum 83% thrombus lyses whenever increase streptokinase concentration. It is very probable to happen because of the presence of high concentration of antiplasmin in the blood that neutralizes around half of the thrombolytic potential of the sanguine plasminogen. The experiment shows also that only free serum plasminogen are available for streptokinase action in order to generate plasmin.

引用

页码：1411 / 1414

页数：4

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