Association of polymorphisms in four low-penetrance genes (ACYP2, CCNE1, ERCC5 and lincRNA CASC22) with breast cancer risk in a Vietnamese population

In breast cancer (BC), four low-penetrance genes (ACYP2, CCNE1, ERCC5 and lincRNA CASC22) are involved in cell cycle arrest, DNA damage repair and long non-coding RNA-mediated regulation is commonly known as causative genes of tumorigenesis. A functional polymorphism in these genes may cause cancer by altering the genes' structure and function. Single Nucleotide Polymorphisms (SNPs) have been discovered to be capable of predicting cancer risk, hence can be used as carcinogenesis markers. To date, the correlation of four SNPs (rs12621038, rs3218038, rs751402 and rs12325489) with BC risk in different populations has been revealed by numerous researches. This study examines the association between these SNPs and the risk of developing BC in Vietnamese women. These four SNPs were genotyped by HRM assay. The differences in allelic and genotypic frequencies between cases and controls were analyzed to determine their relationship with BC risk. While rs12621038, rs3218038 and rs751402 showed no relation to BC, there was an association between rs12325489 and BC risk. In both codominant and overdominant models, the lincRNA CASC22 rs12325489 was consistently associated with BC risk (TT vs. CC: OR = 0.63, 95% CI = 0.44 to 0.90, P = 0.01 and TC vs. TT + CC: OR = 0.61, 95% CI = 0.43 to 0.84, P = 0.003; respectively). These results indicated that rs12325489 could be a potential biomarker for predicting BC risk in Vietnamese women.