Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling

被引：27
|
作者：
Liang, Zhigang [1 ,2 ,3 ]
Wang, Ying [1 ,2 ]
Shen, Zhenya [1 ,2 ]
Teng, Xiaomei [1 ,2 ]
Li, Xinjian [3 ]
Li, Chenwei [3 ]
Wu, Weijie [3 ]
Zhou, Zenghui [3 ]
Wang, Zishan [3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Inst Cardiovasc Sci, Suzhou, Jiangsu, Peoples R China
[3] Ningbo First Hosp, Dept Thorac Surg, Ningbo, Zhejiang, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 08期
关键词：
NSCLC; Fascin; 1; YAP/TEAD signaling; Cell growth; Migration; HIPPO PATHWAY; COLORECTAL-CANCER; F-ACTIN; ADHESION; MECHANOTRANSDUCTION; EXPRESSION; MOTILITY; PROTEIN; ROLES; YAP;
D O I：
10.1007/s13277-016-4934-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fascin 1 (Fascin actin-bundling protein 1) is an actin-binding protein. Although several studies have reported the dysregulation of Fascin 1 in non-small cell lung cancer (NSCLC), its functions in the progression of NSCLC and the related molecular mechanism were not fully understood. In this study, the expression of Fascin 1 in NSCLC tissues was determined using quantitative PCR (qPCR), and the roles of Fascin 1 in the progression of NSCLC were investigated. It was found that both the messenger RNA (mRNA) level and the protein level of Fascin 1 were upregulated in NSCLC tissues. Forced expression of Fascin 1 promoted the growth and migration of NSCLC cells, while knocking down the expression of Fascin 1 inhibited the growth, migration, and tumorigenesis of NSCLC cells. Mechanism studies showed that Fascin 1 increased the transcriptional activity of the YAP/TEAD (Yes-associated protein/TEA domain transcriptional factor) complex, and knocking down the expression of Fascin 1 attenuated the expression of target genes downstream the YAP/TEAD complex. In addition, MST1 interacted with Fascin 1. Taken together, Fascin 1 plays an oncogenic role in NSCLC by activating the transcriptional activity of the YAP/TEAD complex.
引用
收藏
页码：10909 / 10915
页数：7
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