The power of the dark side: Huntington's disease protein and p53 form a deadly alliance

被引：5
|
作者：
La Spada, AR [1 ]
Morrison, RS
机构：
[1] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Med, Seattle, WA 98195 USA
[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA
[4] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA
[5] Univ Washington, Ctr Neurogenet & Neurotherapeut, Seattle, WA 98195 USA
来源：
NEURON | 2005年 / 47卷 / 01期
关键词：
D O I：
10.1016/j.neuron.2005.06.023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A role for apoptotic mediators in neurodegenerative disease has long been considered, but the identity of the putative effectors and the basis of their actions in neurodegeneration remain ill-defined. Huntington's disease (HD) is a polyglutamine disorder whose pathogenesis likely involves mitochondrial dysfunction. In this issue of Neuron, Bae et al. present data implicating p53 in HD pathogenesis. This intriguing study may thus provide a link between nuclear transcription dysregulation and mitochondrial abnormalities in HD.
引用
收藏
页码：1 / 3
页数：3
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