Effects of seco-steroids purified from Physalis angulata L., Solanaceae, on the viability of Leishmania sp.

被引：27

作者：

Guimaraes, Elisalva T. ^{[1
]}

Lima, Milena S. ^{[1
]}

Santos, Luana A. ^{[1
]}

Ribeiro, Ivone M. ^{[2
]}

Tomassini, Therezinha B. C. ^{[2
]}

dos Santos, Ricardo Ribeiro ^{[1
,3
]}

dos Santos, Washington L. C. ^{[1
]}

Soares, Milena B. P. ^{[1
,3
]}

机构：

[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil

[2] Fundacao Oswaldo Cruz, BR-21041050 Rio De Janeiro, Brazil

[3] Hosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2010年 / 20卷 / 06期

关键词：

Leishmania sp; physalins; promastigotes; seco-steroids; TRYPANOCIDAL CONSTITUENTS; AERIAL PARTS; PLANTS; WITHANOLIDES;

D O I：

10.1590/S0102-695X2010005000036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Physalis angulata L., Solanaceae, is an annual herb commonly used in popular medicine in many tropical and subtropical countries. P. angulata extracts contain a variety of substances, but little is known about their pharmacological activities. In this work we investigated the in vitro antileishmanial activity of seco-steroids (physalins) purified from P. angulata. Addition of physalins B, F, and G caused a concentration-dependent inhibition in the growth of L. amazonensis promastigotes, being the IC50 values 6.8, 1.4, and 9.2 mu M, respectively. Physalin D was less active and had an IC50 value of 30.5 mu M. Physalins were also active in cultures of other Leishmania species (L. major, L. braziliensis, and L. chagasi). Our results demonstrate the potent antileishmanial activity of physalins in cultures of Leishmania species of the New and Old Worlds and suggest the therapeutic potential of these seco-steroids in leishmaniasis.

引用

页码：945 / 949

页数：5

共 15 条

[1] Trypanocidal constituents in plants 6.: Minor withanolides from the aerial parts of Physalis angulata [J].

Abe, Fumiko ;

Nagafuji, Shinya ;

Okawa, Masafumi ;

Kinjo, Junei .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (08) :1226-1228

[2] A policy for leishmaniasis with respect to the prevention and control of drug resistance [J].

Bryceson, A .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2001, 6 (11) :928-934

[3]

CHIANG HC, 1992, ANTICANCER RES, V12, P837

[4] New leishmanicidal physalins from Physalis minima [J].

Choudhary, M. Iqbal ;

Yousuf, Sammer ;

Samreen ;

Ahmed, Shakil ;

Atta-Ur-Rahman .

NATURAL PRODUCT RESEARCH, 2007, 21 (10) :877-883

[5] Antileishmanial physalins from Physalis minima [J].

Choudhary, MQ ;

Yousaf, S ;

Ahmed, S ;

Samreen ;

Yasmeen, K ;

Atta-ur-Rahman .

CHEMISTRY & BIODIVERSITY, 2005, 2 (09) :1164-1173

[6] Leishmaniasis phytotherapy. Nature's leadership against an ancient disease [J].

de Carvalho, PB ;

Ferreira, EI .

FITOTERAPIA, 2001, 72 (06) :599-618

[7] MEDICINAL-PLANTS IN THE FIGHT AGAINST LEISHMANIASIS [J].

IWU, MM ;

JACKSON, JE ;

SCHUSTER, BG .

PARASITOLOGY TODAY, 1994, 10 (02) :65-68

[8] Physalins from Witheringia solanacea as modulators off the NF-κB cascade [J].

Jacobo-Herrera, NJ ;

Bremner, P ;

Márquez, N ;

Gupta, MP ;

Gibbons, S ;

Muñoz, E ;

Heinrich, M .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (03) :328-331

[9] Antimycobacterial physalins from Physalis angulata L. (Solanaceae) [J].

Januário, AH ;

Rodrigues, E ;

Pietro, RCLR ;

Kashima, S ;

Sato, DN ;

França, SC .

PHYTOTHERAPY RESEARCH, 2002, 16 (05) :445-448

[10] Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B [J].

Larabi, M ;

Yardley, V ;

Loiseau, PM ;

Appel, M ;

Legrand, P ;

Gulik, A ;

Bories, C ;

Croft, SL ;

Barratt, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (12) :3774-3779

← 1 2 →