Perivascular adipose tissue and vascular disease

被引：106
作者：
Britton, Kathryn A. [1 ,2 ,3 ]
Fox, Caroline S. [2 ,4 ,5 ]
机构：
[1] NHLBI, Farmingham Heart Study, Framingham, MA USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Div Endocrinol Metab & Hypertens, Boston, MA 02115 USA
[5] Ctr Populat Studies, Framingham, MA USA
来源：
CLINICAL LIPIDOLOGY | 2011年 / 6卷 / 01期
关键词：
cardiovascular; epidemiology; imaging; mechanisms; perivascular adipose tissue; NECROSIS-FACTOR-ALPHA; CORONARY ENDOTHELIAL FUNCTION; MUSCLE RESISTANCE ARTERIES; VISCERAL ABDOMINAL FAT; PERICARDIAL FAT; NITRIC-OXIDE; EPICARDIAL FAT; HEART-DISEASE; RISK-FACTORS; PERIADVENTITIAL FAT;
D O I：
10.2217/CLP.10.89
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Perivascular adipose tissue is a local deposit of adipose tissue surrounding the vasculature. Perivascular adipose tissue is present throughout the body and has been shown to have a local effect on blood vessels. The influence of perivascular adipose tissue on the vasculature changes with increasing adiposity. This article describes the anatomy and pathophysiology of perivascular adipose tissue and the experimental evidence supporting its local adverse effect on the vasculature. Methods for quantifying perivascular adipose tissue in free-living populations will be described. Finally, the epidemiological literature demonstrating an association between perivascular adipose tissue and cardiometabolic disease will be explored.
引用
收藏
页码：79 / 91
页数：13
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