(Re)Solution of a Protein Fold Without Solution

被引：2

作者：

Barran, Perdita E. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh, Midlothian, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 14期

基金：

奥地利科学基金会;

关键词：

gas-phase conformations; mass spectrometry; protein structures; structure elucidation; MASS-SPECTROMETRY; ELECTROSPRAY;

D O I：

10.1002/anie.201007231

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Who needs water? The gas phase may seem an esoteric place to examine the structures of proteins, but a new study reveals that the solution fold of the protein KIX can be retained for significant time periods in a mass spectrometer. Once in this ideal laboratory environment, details of the higher order fold can be elucidated at the single amino acid level. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3120 / 3122

页数：3

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