LPS-induced changes in myocardial markers in neonatal rats

被引:5
|
作者
Ravindranath, TM
Goto, M
Bakr, S
Ramasamy, R
机构
[1] Loyola Univ, Med Ctr, Ronald McDonald Childrens Hosp, Dept Pediat,Div Crit Care Med, Maywood, IL 60153 USA
[2] Loyola Univ, Med Ctr, Shock Trauma Inst, Maywood, IL 60153 USA
[3] Columbia Univ, Coll Phys & Surg, New York, NY USA
来源
BIOLOGY OF THE NEONATE | 2003年 / 84卷 / 04期
关键词
neonatal endotoxic shock; cardiac lipid metabolism; rat pups; cardiac redox state; TNF-alpha;
D O I
10.1159/000073641
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Lipopolysaccharide (LPS) produces varied systemic metabolic effects. We studied the effects of LPS on the cardiac fatty acid profile and its relationship to energy metabolism and inflammatory mediators that included TNF-alpha and nitric oxide synthase (NOS) in 10-day-old neonatal rat pups. Rat pups received an i.p. injection of LPS after a 4-hour starvation period, followed by collection of blood and cardiac tissue 4 h following LPS administration. Compared to controls, LPS induced significant hypoglycemia and hyperlactacidemia, suggesting the development of endotoxic shock. The result was a significant depression in total fatty acid levels as well as non-esterified fatty acid in the cardiac tissue of the LPS-treated pups. In addition, LPS-treated pups also showed a significant increase in TNF-alpha, NOS levels with a depressed redox state and energy metabolism in cardiac tissue. These observations suggest that endotoxic shock in 10-day-old rat pups induces a systemic inflammatory response with a depression in fatty acid metabolism that may contribute to myocardial failure. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码:319 / 324
页数:6
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