Sulphur metabolism in colon cancer tissues: a case report and literature review

被引：5

作者：

Fukuoka, Hironori ^{[1
]}

Andou, Tomohiro ^{[2
]}

Moriya, Takeo ^{[2
]}

Narita, Koji ^{[3
]}

Kasahara, Ken ^{[3
]}

Miura, Daisuke ^{[4
]}

Sekiguchi, Yuji ^{[4
]}

Suzuki, Shinsuke ^{[5
]}

Nakagawa, Kazuya ^{[1
]}

Ozawa, Mayumi ^{[1
]}

Ishibe, Atsushi ^{[1
]}

Endo, Itaru ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Gastroenterol Surg, Yokohama, Kanagawa, Japan

[2] Axcelead Drug Discovery Partners Inc, Fujisawa, Kanagawa, Japan

[3] Chitose Lab Corp, Kawasaki, Kanagawa, Japan

[4] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Tsukuba, Ibaraki, Japan

[5] Fujisawa Shonandai Hosp, Fujisawa, Kanagawa, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2021年 / 49卷 / 11期

关键词：

Case report; sulphur metabolites; colon cancer tissue; cysteine persulfide; cysteine trisulfide; TUMOR HYPOXIA; CYSTEINE; GSSH;

D O I：

10.1177/03000605211059936

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sulphur-containing compounds have been linked to colorectal cancer by factors such as the presence of methyl mercaptan in intestinal gas and long-term dietary intake associated with sulphur-metabolizing microbiota. Therefore, this current case report hypothesized that active sulphur metabolism in colorectal cancer results in the formation of sulphur compounds in the intestine and, thus, examined sulphur metabolites possibly associated with sulphur respiration in colon cancer tissues. The patient was a 73-year-old female that underwent laparoscopic right hemicolectomy for ascending colon cancer. During the surgery, colon cancer tissues and normal intestinal mucosa samples were collected. After optimizing the sample concentrations for homogenization (pre-treatment), the samples were stabilized using a hydroxyphenyl-containing derivative and the relevant metabolites were quantified using liquid chromatography with tandem mass spectrometry. The results showed that cysteine persulfide and cysteine trisulfide levels were higher in colon cancer tissues than in normal mucosal tissues. Thus, sulphur metabolism, possibly sulphur respiration, is enhanced in colon cancer tissues.

引用

页数：9

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