Symplostatin 1:: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

被引：124

作者：

Harrigan, GG

Luesch, H

Yoshida, WY

Moore, RE ^{[1
]}

Nagle, DG

Paul, VJ

Mooberry, SL

Corbett, TH

Valeriote, FA

机构：

[1] Univ Hawaii, Dept Chem, Honolulu, HI 96822 USA

[2] Canc Res Ctr Hawaii, Honolulu, HI 96813 USA

[3] Univ Guam, Marine Lab, UOG Stn, Mangilao, GU 96923 USA

[4] Wayne State Univ, Karmanos Canc Ctr, Detroit, MI 48201 USA

[5] Wayne State Univ, Dept Internal Med, Detroit, MI 48201 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 09期

关键词：

D O I：

10.1021/np980321c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

引用

页码：1075 / 1077

页数：3

共 13 条

[1]

CAREFOOT TH, 1987, OCEANOGR MAR BIOL, V25, P167

[2]

CORBETT TH, 1993, CYTOTOXIC ANTICANCER, P35

[3]

CROBETT T, 1997, ANTICANCER DRUG DEV, P75

[4]

HARRIGAN GG, 1998, IN PRESS J NAT PROD, V61

[5]

KAMANO Y, 1989, Patent No. 4816444

[6] Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula [J].

Orjala, J ;

Gerwick, WH .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (04) :427-430

[7] ISOLATION OF DOLASTATINS 10-15 FROM THE MARINE MOLLUSK DOLABELLA-AURICULARIA [J].

PETTIT, GR ;

KAMANO, Y ;

HERALD, CL ;

FUJII, Y ;

KIZU, H ;

BOYD, MR ;

BOETTNER, FE ;

DOUBEK, DL ;

SCHMIDT, JM ;

CHAPUIS, JC ;

MICHEL, C .

TETRAHEDRON, 1993, 49 (41) :9151-9170

[8] ANTINEOPLASTIC AGENTS .136. THE ISOLATION AND STRUCTURE OF A REMARKABLE MARINE ANIMAL ANTINEOPLASTIC CONSTITUENT - DOLASTATIN 10 [J].

PETTIT, GR ;

KAMANO, Y ;

HERALD, CL ;

TUINMAN, AA ;

BOETTNER, FE ;

KIZU, H ;

SCHMIDT, JM ;

BACZYNSKYJ, L ;

TOMER, KB ;

BONTEMS, RJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (22) :6883-6885

[9] Progress in the discovery of biosynthetic anticancer drugs [J].

Pettit, GR .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (08) :812-821

[10]

PETTIT GR, 1997, Patent No. 5663149

← 1 2 →