Ziziphus spinosa seeds for insomnia: A review of chemistry and psychopharmacology

被引：56

作者：

Shergis, Johannah Linda ^{[1
]}

Ni, Xiaojia ^{[1
,2
,3
]}

Sarris, Jerome ^{[4
,5
,6
]}

Zhang, Anthony Lin ^{[1
]}

Guo, Xinfeng ^{[2
,3
]}

Xue, Charlie C. ^{[1
,2
,3
]}

Lu, Chuanjian ^{[2
,3
]}

Hugel, Helmut ^{[7
]}

机构：

[1] RMIT Univ, Sch Hlth & Biomed Sci, China Australia Int Res Ctr Chinese Med, POB 71, Bundoora, Vic 3083, Australia

[2] Guangdong Prov Acad Chinese Med Sci, Guangdong Prov Hosp Chinese Med, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Clin Coll 2, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China

[4] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3121, Australia

[5] Univ Melbourne, Melbourne Clin, Melbourne, Vic 3121, Australia

[6] Swinburne Univ Technol, Ctr Human Psychopharmacol, POB 218, Hawthorn, Vic 3122, Australia

[7] RMIT Univ, Sch Sci, POB 2476, Melbourne, Vic 3001, Australia

来源：

PHYTOMEDICINE | 2017年 / 34卷

关键词：

Ziziphus spinosa; Zizyphus; Suan zao ren; Insomnia; Phytochemical; Psychopharmacology; INDUCED SLEEPING BEHAVIORS; CHINESE HERBAL MEDICINE; SUBUNIT MESSENGER-RNAS; JUJUBOSIDE-A; IN-VITRO; CYCLOPEPTIDE ALKALOIDS; SUANZAOREN DECOCTION; SEROTONERGIC SYSTEM; TISSUE DISTRIBUTION; GABAERGIC SYSTEMS;

D O I：

10.1016/j.phymed.2017.07.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Background: In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. Purpose/Sections: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. Conclusions: ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.

引用

页码：38 / 43

页数：6

共 70 条

[1] Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice [J].

Adzu, B ;

Amos, S ;

Dzarma, S ;

Wambebe, C ;

Gamaniel, K .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 79 (01) :13-16

[2]

[Anonymous], EVID BASED COMPLEMEN

[3]

Bensky D., 2004, Chinese Herbal Medicine: Materia Medica, V3rd Edition

[4] Insomnia [J].

Buysse, Daniel J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (07) :706-716

[5] Hypnotic effect of jujubosides from Semen Ziziphi Spinosae [J].

Cao, Jie-Xin ;

Zhang, Qing-Ying ;

Cui, Su-Ying ;

Cui, Xiang-Yu ;

Zhang, Juan ;

Zhang, Yong-He ;

Bai, Yan-Jing ;

Zhao, Yu-Ying .

JOURNAL OF ETHNOPHARMACOLOGY, 2010, 130 (01) :163-166

[6] What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation [J].

Chen, Calvin Yu-Chian ;

Chen, Yuh-Fung ;

Wu, Chieh-Hsi ;

Tsai, Huei-Yann .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2008, 26 (01) :57-64

[7] Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002 [J].

Chen, Fang-Pey ;

Jong, Maw-Shiou ;

Chen, Yu-Chun ;

Kung, Yen-Ying ;

Chen, Tzeng-Ji ;

Chen, Fun-Jou ;

Hwang, Shinn-Jang .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011

[8]

Chinese Pharmacopoeia Committee, 2015, PHARM PEOPL REP CHIN

[9] GABAA receptors and benzodiazepines:: a role for dendritic resident subunit mRNAs [J].

Costa, E ;

Auta, J ;

Grayson, DR ;

Matsumto, K ;

Pappas, GD ;

Zhang, X ;

Guidotti, A .

NEUROPHARMACOLOGY, 2002, 43 (06) :925-937

[10] Mechanism of action of the hypnotic zolpidem in vivo [J].

Crestani, F ;

Martin, JR ;

Möhler, H ;

Rudolph, U .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (07) :1251-1254

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