A FRET-based Ratiometric Fluorescent Probe for Nitroxyl Detection in Living Cells

被引：95

作者：

Zhang, Huatang ^{[1
,2
]}

Liu, Ruochuan ^{[1
]}

Tan, Yi ^{[1
]}

Xie, William Haowei ^{[1
]}

Lei, Haipeng ^{[1
]}

Cheung, Hon-Yeung ^{[2
,3
]}

Sun, Hongyan ^{[1
,2
]}

机构：

[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China

[2] City Univ Hong Kong, Shenzhen Res Inst, Biotech & Hlth Ctr, Key Lab Biochip Technol, Shenzhen, Peoples R China

[3] City Univ Hong Kong, Dept Biomed Sci, Kowloon, Hong Kong, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 09期

基金：

美国国家科学基金会;

关键词：

FRET probe; HNO; ratiometric; bioimaging; fluorescent probe; NITRIC-OXIDE; AQUEOUS-SOLUTION; REDUCTANT-RESISTANT; IN-VIVO; HNO; DESIGN; AGENT; ENHANCEMENT; MECHANISM; STRATEGY;

D O I：

10.1021/am508987v

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

HNO has recently been found to possess distinct biological functions from NO. Studying the biological functions of HNO calls for the development of sensitive and selective fluorescent probes. Herein, we designed and synthesized a FRET-based ratiometric probe to detect HNO in living cells. Our studies revealed that the probe is capable of detecting HNO in a rapid and ratiometric manner under physiological conditions. In bioimaging studies, the probe displayed a clear color change from blue to green when treated with HNO.

引用

页码：5438 / 5443

页数：6

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