Effectiveness of ADC Difference Value on Pre-neoadjuvant Chemotherapy MRI for Response Evaluation of Breast Cancer

被引:7
作者
Choi, Bo Bae [1 ]
机构
[1] Chungnam Natl Univ Hosp, Daejeon, South Korea
关键词
breast cancer; magnetic resonance imaging; diffusion-weighted imaging; apparent diffusion coefficient; breast cancer diagnosis; breast cancer treatment; CONTRAST-ENHANCED MRI; PRETREATMENT PREDICTION; TEXTURE ANALYSIS; DIAGNOSTIC-ACCURACY; HETEROGENEITY; TUMORS; ASSOCIATIONS; RECURRENCE; SURVIVAL; FEATURES;
D O I
10.1177/15330338211039129
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Neoadjuvant chemotherapy (NAC) is known to be a suitable treatment and first-line defense for locally advanced breast cancer. However, the NAC response may include unexpected outcomes, and it is not easy to predict the NAC response precisely. Especially, early detection of those patients who do not benefit from NAC is needed to reduce unnecessary therapy and side effects. Objective: The purpose of this study was to determine whether the pretreatment apparent diffusion coefficient (ADC) value is effective for predicting the response of breast cancer to NAC. Method: Forty-nine breast cancer cases with pre- and post-NAC breast MRI were enrolled. MRI was performed using a 1.5-T scanner with the basic protocol including diffusion-weighted imaging. ADC difference value (ADC-diff) was calculated in all cases. Results: ADC-diff was high in complete response and partial response cases (p < .05). ADC-diff correlated with the DWI rim sign, with a positive DWI rim sign being associated with a higher ADC-diff (p < .05). Conclusion: High-ADC difference value on the pretreatment MRI can provide information for a better response of NAC on breast cancer.
引用
收藏
页数:8
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