Possibility and potential of a vaccine against human chorionic gonadotropin for family planning

被引：0

作者：

Purswani, Shilpi ^{[1
]}

Lohiya, N. K. ^{[2
]}

Talwar, G. P. ^{[1
]}

机构：

[1] Talwar Res Fdn, New Delhi 110068, India

[2] Univ Rajasthan, Dept Zool, Jaipur 302004, Rajasthan, India

来源：

CURRENT SCIENCE | 2010年 / 99卷 / 02期

关键词：

Efficacy; human chorionic gonadotropin; recombinant vaccine; safety; OVINE LUTEINIZING-HORMONE; LONG-TERM IMMUNIZATION; FREE BETA-SUBUNIT; PREVENTS PREGNANCY; PROGNOSTIC MARKER; ANTIBODY-RESPONSE; HCG-BETA; WOMEN; SERUM; EXPRESSION;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human chorionic gonadotropin (hCG) is a unique hormone produced soon after fertilization in women. It is an ideal target for contraception. Antibodies against hCG prevent pregnancy without blocking ovulation and derangement of menstrual regularity. Previous work on development of a vaccine against hCG is reviewed including the first ever safety and efficacy trials in women with a birth control vaccine. The possibility of a recombinant vaccine with enhanced immunogenicity is indicated.

引用

页码：169 / 176

页数：8

共 60 条

[1]

ALFTHAN H, 1992, CANCER RES, V52, P4628

[2] Infertility caused by hCG autoantibody [J].