Alloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice

被引：23
作者：
Zhang, Xiangrui [1 ]
Retyunskiy, Vladimir [1 ]
Qiao, Shuai [1 ]
Zhao, Ye [1 ]
Tzeng, Chi-Meng [2 ,3 ,4 ]
机构：
[1] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211800, Peoples R China
[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
[3] Xiamen Univ, Translat Med Res Ctr, Sch Pharmaceut Sci, Key Lab Canc T Cell Theragnost & Clin Translat, Xiamen 361005, Peoples R China
[4] Xiamen Chang Gung Hosp, Med Res Ctr, Xiamen 361005, Fujian, Peoples R China
来源：
SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
VASCULAR-PERMEABILITY; DOWN-REGULATION; NITRIC-OXIDE; ACTIVATION; BRADYKININ; PEPTIDES; ANALOGS; INNATE; IL-12;
D O I：
10.1038/s41598-022-20648-z
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alloferon-1 have been proposed as an effective peptide to enhance antitumoral immunity, antiviral defense and anti-inflammatory activity. This work aimed to assess anti-inflammatory effects of alloferon-1 against acute inflammation and histopathological deformations in lambda-carrageenan-induced paw edema in mice. Systemic pretreatment with alloferon-1 (22.0 mg/kg) intraperitoneally injected mice showed a significant reduction in paw thickness and vascular permeability. Alloferon-1 prevented lambda-carrageenan-evoked exudation and the neutrophil influx to the mouse pleura and the neutrophil migration into carrageenan-stimulated mouse air pouches based on the histopathological changes in the paw tissues. Administration of alloferon-1 also suppressed the expression of the inflammatory cytokines in the inflamed paw tissues such as tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP1), interleukin-5 (IL-5), etc. detected by Luminex liquid chip. Collectively, the present study provides evidences for the marked anti-inflammatory effects of alloferon-1 which might represent new therapeutic options for the treatment of acute inflammatory diseases.
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页数：10
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