Allelic imbalance on chromosome 13q: Evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer

被引：0
|
作者：
Hamann, U
Herbold, C
Costa, S
Solomayer, EF
Kaufmann, M
Bastert, G
Ulmer, HU
Frenzel, H
Komitowski, D
机构：
[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,DIV HISTODIAGNOST & PATHOMORPHOL DOCUMENTAT,D-69120 HEIDELBERG,GERMANY
[2] UNIV FRANKFURT KLINIKUM,D-60590 FRANKFURT,GERMANY
[3] UNIV KLINIKUM HEIDELBERG,D-69115 HEIDELBERG,GERMANY
[4] STADT KLINIKUM,D-76133 KARLSRUHE,GERMANY
来源：
CANCER RESEARCH | 1996年 / 56卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, the breast cancer susceptibility gene BRCA2 has been identified in chromosome 13q, a region that also contains the retinoblastoma gene RB1. To elucidate a possible role of BRCA2 and RB1 in sporadic breast tumorigenesis, allelic imbalance (AI) at 13q loci was examined in 78 primary sporadic breast tumors. AI was found in 52 - 63% of tumors. Nine tumors showed AI only in the BRCA2 region but not at RBI. Six tumors showed AI at RBI but not in the BRCA2 region. AI in the BRCA2 region correlated significantly with aneuploidy (P = 0.032) and AI at RBI with small tumor size (P = 0.025). Our data suggest that BRCA2 and RBI mag be both distinct target loci for AI on chromosome 13 in sporadic breast cancer.
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页码：1988 / 1990
页数：3
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