Bisphenol A: Food Exposure and Impact on Human Health

被引:381
作者
Almeida, Susana [1 ]
Raposo, Antonio [1 ]
Almeida-Gonzalez, Maira [2 ]
Carrascosa, Conrado [3 ]
机构
[1] Univ Lusofona Humanidades & Tecnol, CBIOS Res Ctr Biosci & Hlth Technol, Campo Grande 376, P-1749024 Lisbon, Portugal
[2] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Toxicol Unit, Paseo Blas Cabrera S-N, Las Palmas Gran Canaria 35016, Spain
[3] Univ Las Palmas Gran Canaria, Fac Vet, Dept Anim Pathol & Prod Bromatol & Food Technol, Trasmontana S-N, Arucas 35413, Spain
关键词
bisphenol A; epoxy resins; food exposure; health; toxicity; POLYCARBONATE BABY BOTTLES; ENDOCRINE DISRUPTOR; ENVIRONMENTAL CHEMICALS; WIDESPREAD EXPOSURE; REPRODUCTIVE HEALTH; PRENATAL EXPOSURE; URINARY LEVELS; ERR-GAMMA; MIGRATION; BPA;
D O I
10.1111/1541-4337.12388
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Bisphenol A (BPA) is an industrial compound used extensively to produce synthetic polymers, such as epoxy resins, which are incorporated into the inner coating of metal cans, and also to manufacture polycarbonates with applications in bottles, including bottles of water. Several studies have reported on the transfer of this compound to food. Regarding human exposure to BPA, food intake can be considered the most serious among all the routes, not only because it potentially reaches more people in different age groups (including infants, an especially vulnerable group), but also because it inadvertently occurs over long time periods. BPA is considered an endocrine disruptor and several studies have proposed a relationship between exposure to BPA and the appearance of adverse health effects, such as cancer, infertility, diabetes, and obesity, among others. In 2015 however, the European Food Safety Authority concluded in its last scientific opinion that this compound does not pose any risk to the exposed population's health. Therefore, the EU regards BPA as an authorized product to be used as food contact material. Although BPA intake through food is apparently below the set limits, research into BPA and its potential negative effects is still ongoing. This review contains the most recent in vitro and in vivo studies on BPA toxicity and its harmful effects on health, and it intends to address human exposure to BPA, namely through dietary exposure and its impact on human health.
引用
收藏
页码:1503 / 1517
页数:15
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