Off-target effects of cytidine base editor and adenine base editor: What can we do?

被引：2
|
作者：
Liang, Puping [1 ,2 ,3 ,4 ]
Wen, Jinkun [1 ,2 ,3 ,4 ,5 ]
Huang, Junjiu [1 ,2 ,3 ,4 ,6 ]
机构：
[1] Sun Yat Sen Univ, Sch Life Sci, Key Lab Reprod Med Guangdong Prov, Guangzhou 510275, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Peoples R China
[3] Sun Yat Sen Univ, Sch Life Sci, SYSU BCM Joint Res Ctr, MOE Key Lab Gene Funct & Regulat, Guangzhou 510275, Peoples R China
[4] Sun Yat Sen Univ, Sch Life Sci, SYSU BCM Joint Res Ctr, Guangzhou Key Lab Hlth Aging Res, Guangzhou 510275, Peoples R China
[5] Sun Yat Sen Univ, Jiangmen Cent Hosp, Affiliated Jiangmen Hosp, Guangzhou 510150, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 3, Key Lab Reprod Med Guangdong Prov, Guangzhou 510150, Peoples R China
来源：
JOURNAL OF GENETICS AND GENOMICS | 2019年 / 46卷 / 11期
基金：
国家重点研发计划;
关键词：
GENOMIC DNA; RNA; DEAMINASE;
D O I：
10.1016/j.jgg.2019.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：509 / 512
页数：4
相关论文
共 50 条
  • [31] Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase
    Tong, Huawei
    Wang, Xuchen
    Liu, Yuanhua
    Liu, Nana
    Li, Yun
    Luo, Jiamin
    Ma, Qian
    Wu, Danni
    Li, Jiyong
    Xu, Chunlong
    Yang, Hui
    NATURE BIOTECHNOLOGY, 2023, 41 (08) : 1080 - +
  • [32] Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis
    Kang, Yu
    Dai, Shaoxing
    Zeng, Yuqiang
    Wang, Fang
    Yang, Pengpeng
    Yang, Zhaohui
    Pu, Youwei
    Li, Zifan
    Chen, Xinglong
    Tian, Baohong
    Si, Wei
    Ji, Weizhi
    Niu, Yuyu
    SCIENCE ADVANCES, 2022, 8 (29)
  • [33] Genome-wide profiling of adenine base editor specificity by EndoV-seq
    Liang, Puping
    Xie, Xiaowei
    Zhi, Shengyao
    Sun, Hongwei
    Zhang, Xiya
    Chen, Yu
    Chen, Yuxi
    Xiong, Yuanyan
    Ma, Wenbin
    Liu, Dan
    Huang, Junjiu
    Zhou Songyang
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [34] A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
    Grunewald, Julian
    Zhou, Ronghao
    Lareau, Caleb A.
    Garcia, Sara P.
    Iyer, Sowmya
    Miller, Bret R.
    Langner, Lukas M.
    Hsu, Jonathan Y.
    Aryee, Martin J.
    Joung, J. Keith
    NATURE BIOTECHNOLOGY, 2020, 38 (07) : 861 - U27
  • [35] Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
    Wang, Xinjie
    Liu, Zhiwei
    Li, GuangLei
    Dang, Lu
    Huang, Shisheng
    He, Lei
    Ma, Yu'e
    Li, Cong
    Liu, Ming
    Yang, Guang
    Huang, Xingxu
    Zhou, Fei
    Ma, Xiaodong
    MOLECULAR THERAPY, 2020, 28 (02) : 431 - 440
  • [36] Adenine base editor-mediated splicing remodeling activates noncanonical splice sites
    Liu, Yuanyuan
    Li, Qing
    Yan, Tong
    Chen, Haoran
    Wang, Jiahua
    Wang, Yingyi
    Yang, Yeqin
    Xiang, Lue
    Chi, Zailong
    Ren, Kaiqun
    Lin, Bin
    Lin, Ge
    Li, Jinsong
    Liu, Yong
    Gu, Feng
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (12)
  • [37] DNA Base Editing Induces Substantial Off-target RNA Mutations and Their Elimination by Mutagenesis
    ION
    Bulletin of the Chinese Academy of Sciences, 2019, 33 (02) : 111 - 112
  • [38] Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
    Grunewald, Julian
    Zhou, Ronghao
    Garcia, Sara P.
    Iyer, Sowmya
    Lareau, Caleb A.
    Aryee, Martin J.
    Joung, J. Keith
    NATURE, 2019, 569 (7756) : 433 - +
  • [39] Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
    Jiang, Tingting
    Henderson, Jordana M.
    Coote, Kevin
    Cheng, Yi
    Valley, Hillary C.
    Zhang, Xiao-Ou
    Wang, Qin
    Rhym, Luke H.
    Cao, Yueying
    Newby, Gregory A.
    Bihler, Hermann
    Mense, Martin
    Weng, Zhiping
    Anderson, Daniel G.
    McCaffrey, Anton P.
    Liu, David R.
    Xue, Wen
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [40] Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
    Yu, Yi
    Leete, Thomas C.
    Born, David A.
    Young, Lauren
    Barrera, Luis A.
    Lee, Seung-Joo
    Rees, Holly A.
    Ciaramella, Giuseppe
    Gaudelli, Nicole M.
    NATURE COMMUNICATIONS, 2020, 11 (01)
12345